Pub. Date : 2008 Dec 15
PMID : 19088030
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 2 | The plasma AUCi.v.s of 7OH-MTX were 6.0-fold and 4.3-fold increased in Abcc2(-/-) and Abcc2;Abcc3(-/-) mice, respectively, leading to increased urinary excretion. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 3 | The plasma AUCi.v.s of 7OH-MTX were 6.0-fold and 4.3-fold increased in Abcc2(-/-) and Abcc2;Abcc3(-/-) mice, respectively, leading to increased urinary excretion. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 4 | The biliary excretion of 7OH-MTX was 5.8-fold reduced in Abcc2(-/-) but unchanged in Abcc2;Abcc3(-/-) mice. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 5 | 7OH-MTX accumulated substantially in the liver of Abcc2(-/-) and especially Abcc2;Abcc3(-/-) mice. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 6 | 7OH-MTX accumulated substantially in the liver of Abcc2(-/-) and especially Abcc2;Abcc3(-/-) mice. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 7 | CONCLUSIONS: Abcc2 is important for (biliary) excretion of MTX and its toxic metabolite 7OH-MTX. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 8 | When Abcc2 is absent, Abcc3 transports MTX and 7OH-MTX back from the liver into the circulation, leading to increased plasma levels and urinary excretion. | 7-hydroxymethotrexate | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |