Title : Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2.

Pub. Date : 2009 Feb

PMID : 19067785






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 P-gp reduced (99m)Tc-MIBI transport across the BBB of P-gp-deficient mice 2.2-fold, as confirmed by PSC833 and GF120918 inhibition. Technetium Tc 99m Sestamibi phosphoglycolate phosphatase Mus musculus
2 P-gp reduced (99m)Tc-MIBI transport across the BBB of P-gp-deficient mice 2.2-fold, as confirmed by PSC833 and GF120918 inhibition. Technetium Tc 99m Sestamibi phosphoglycolate phosphatase Mus musculus
3 (99m)Tc-MIBI transport at the BBB is restricted by P-gp but not by Mrp1 or Bcrp. Technetium Tc 99m Sestamibi phosphoglycolate phosphatase Mus musculus