Title : Apoptotic histone modification inhibits nuclear transport by regulating RCC1.

Pub. Date : 2009 Jan

PMID : 19060893






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We have found that the nuclear RanGTP level is diminished during the early stages of apoptosis, which correlates with immobilization of RCC1 on the chromosomes. rangtp regulator of chromosome condensation 1 Homo sapiens
2 Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus. rangtp regulator of chromosome condensation 1 Homo sapiens