Title : ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.

Pub. Date : 2008 Dec 1

PMID : 19047152






1 Functional Relationships(s)
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1 This work implicates polyamine biosynthesis as an arbiter of MYCN oncogenesis and shows initial efficacy for polyamine depletion strategies in neuroblastoma, a strategy that may have utility for this and other MYC-driven embryonal tumors. Polyamines myelocytomatosis oncogene Mus musculus