Title : Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.

Pub. Date : 2009 Apr

PMID : 19034627






1 Functional Relationships(s)
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1 Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors. ginkgolide A nuclear receptor subfamily 1 group I member 3 Homo sapiens