Title : Regulation of hepatic energy metabolism by epidermal growth factor.

Pub. Date : 1991 May 8

PMID : 1903108






1 Functional Relationships(s)
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1 While the inactive phorbol ester 4 alpha-phorbol 12,13-didecanoate did not modulate the hepatic actions of EGF, activation of protein kinase C by 4 beta-phorbol 12-myristate 13-acetate (70 nM) abolished the ability of EGF to stimulate gluconeogenesis, tricarboxylic acid cycle activity and metabolic flux through the 2-oxoglutarate dehydrogenase complex. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus