Title : Kinetic modelling of NSAID action on COX-1: focus on in vitro/in vivo aspects and drug combinations.

Pub. Date : 2009 Jan 31

PMID : 19028575






5 Functional Relationships(s)
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1 The developed models were applied to calculate the dose-dependence of aspirin and celecoxib action on COX- 1 in vitro and in vivo conditions. Celecoxib mitochondrially encoded cytochrome c oxidase I Homo sapiens
2 Simulation of the combined effect of two NSAIDs, aspirin and celecoxib, on COX-1 allowed us to reveal the mechanism underlying the suppression of aspirin-mediated COX-1 inhibition by celecoxib. Celecoxib mitochondrially encoded cytochrome c oxidase I Homo sapiens
3 Simulation of the combined effect of two NSAIDs, aspirin and celecoxib, on COX-1 allowed us to reveal the mechanism underlying the suppression of aspirin-mediated COX-1 inhibition by celecoxib. Celecoxib mitochondrially encoded cytochrome c oxidase I Homo sapiens
4 Simulation of the combined effect of two NSAIDs, aspirin and celecoxib, on COX-1 allowed us to reveal the mechanism underlying the suppression of aspirin-mediated COX-1 inhibition by celecoxib. Celecoxib mitochondrially encoded cytochrome c oxidase I Homo sapiens
5 Simulation of the combined effect of two NSAIDs, aspirin and celecoxib, on COX-1 allowed us to reveal the mechanism underlying the suppression of aspirin-mediated COX-1 inhibition by celecoxib. Celecoxib mitochondrially encoded cytochrome c oxidase I Homo sapiens