Title : QSAR and complex network study of the chiral HMGR inhibitor structural diversity.

Pub. Date : 2009 Jan 1

PMID : 19026553






1 Functional Relationships(s)
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1 Efficient drugs such as statins or mevinic acids are inhibitors of the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGR), an enzyme responsible for the double reduction of 3-hydroxy-3-methyl-glutaryl coenzyme A into mevalonic acid. Mevalonic Acid high mobility group AT-hook 1 Homo sapiens