Title : Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.

Pub. Date : 2009 Mar 15

PMID : 19022679






1 Functional Relationships(s)
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1 By exploiting a Still-Gennari HWE coupling with a common C11-C26 aldehyde, a series of C2-C6 modified analogues of the microtubule-stabilising marine natural product dictyostatin were synthesised and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including the (P-glycoprotein efflux-mediated) Taxol-resistant NCI/ADR cell line. dictyostatin aldo-keto reductase family 1 member C4 Homo sapiens