Pub. Date : 1991 May
PMID : 1902169
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that both PTH and IL-1 stimulated the release of PGE2 and 6-keto-PGF1 alpha (the stable metabolite of PGI2). | Dinoprostone | interleukin 1 complex | Mus musculus |
| 2 | Moreover, IL-1 showed 2- to 3-fold greater efficacy than PTH in stimulating PGE2 release. | Dinoprostone | interleukin 1 complex | Mus musculus |
| 3 | IL-1 (60 pM) and PTH (2.4 nM) stimulation of PGE2 production showed a similar time course, with a lag phase of 0.75-1.5 h. Cortisol (1-100 nM) reduced basal PGE2 production and calcium release. | Dinoprostone | interleukin 1 complex | Mus musculus |
| 4 | In bones labeled with [3H]AA, IL-1 and PTH increased [3H]PGE2 and [3H]6-keto-PGF1 alpha release, as measured by HPLC and TLC. | Dinoprostone | interleukin 1 complex | Mus musculus |
| 5 | mRNA was increased by both PTH and IL-1 to a similar extent despite the greater effect of IL-1 on PGE2 production. | Dinoprostone | interleukin 1 complex | Mus musculus |