Title : The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.

Pub. Date : 2008 Dec 1

PMID : 19017959






1 Functional Relationships(s)
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1 The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one Fc epsilon receptor Ia Homo sapiens