Title : Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1.

Pub. Date : 2008 Dec

PMID : 19016528






3 Functional Relationships(s)
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1 In cells expressing IL-10R1-WT, cmvIL-10 (both non-glycosylated- and HeLa-expressed) resulted in equal or slightly stronger STAT3 phosphorylation compared with hIL-10. cmvil-10 signal transducer and activator of transcription 3 Homo sapiens
2 In clones expressing IL-10R1-SNP3, IL-10R1-SNP4 or IL-10R1-SNP3+4, the cmvIL-10 showed significantly less STAT3 phosphorylation, especially when HeLa-expressed cytokines were used. cmvil-10 signal transducer and activator of transcription 3 Homo sapiens
3 Time course experiments demonstrated a slower kinetic of cmvIL-10 STAT3 activation through the variant IL-10R1. cmvil-10 signal transducer and activator of transcription 3 Homo sapiens