Title : Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1.

Pub. Date : 2009 Mar 25

PMID : 19010388






1 Functional Relationships(s)
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1 In contrast, 7-ketocholesterol (7-KC) did not inhibit 11beta-HSD1 in HEK-293 cells, even in the presence of H6PDH, but inhibited 11beta-HSD1 reductase activity in differentiated THP-1 macrophages (IC(50) 8.1+/-0.9microM). 7-ketocholesterol RNA, U1 small nuclear 1 Homo sapiens