Pub. Date : 2009 May
PMID : 19002496
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quantitative RT-PCR showed that sirolimus down-regulated the mRNA expression of VEGF and HIF-1a, but not of bFGF, and TGF-b in MHCC97H cells. | Sirolimus | vascular endothelial growth factor A | Homo sapiens |
| 2 | Furthermore, western blot analysis confirmed that sirolimus also decreased expression of HIF-1a at protein level, in parallel with the down-regulation of the levels of VEGF protein excretion in a time-dependent manner as compared to untreated control cells following anoxia. | Sirolimus | vascular endothelial growth factor A | Homo sapiens |
| 3 | CONCLUSIONS: The immunosuppressive macrolide sirolimus prevents the growth and metastatic progression of HCC, and suppresses VEGF synthesis and secretion by downregulating HIF-1a expression. | Sirolimus | vascular endothelial growth factor A | Homo sapiens |