Pub. Date : 2008 Nov
PMID : 19001435
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | In addition, sorafenib inhibited phosphorylation of signal transducer and activator of transcription 3 (STAT3) in both cell lines and primary tumor cells. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | In addition, sorafenib inhibited phosphorylation of signal transducer and activator of transcription 3 (STAT3) in both cell lines and primary tumor cells. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Together, our data show that sorafenib blocks STAT3 signaling as well as expression of cell cycle and apoptosis regulatory proteins, associated with inhibition of cell proliferation and induction of apoptosis in medulloblastomas. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |