Title : Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis.

Pub. Date : 2008 Nov 1

PMID : 18974153






3 Functional Relationships(s)
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1 Ectopic PSMA expression on PC-3 cells increased the invasive capacity of cells in in vitro invasion assays, which could be competed out by folic acid. Folic Acid folate hydrolase 1 Homo sapiens
2 These results suggest PSMA facilitates the development of prostate cancer, and the invasive ability of these cells may be modulated by folate levels. Folic Acid folate hydrolase 1 Homo sapiens
3 These findings show a novel mechanism that may contribute to the known role of folate in cancer prevention, and may lead to the use of PSMA inhibitors as novel chemopreventive agents for prostate cancer. Folic Acid folate hydrolase 1 Homo sapiens