Title : New approaches to target microsomal triglyceride transfer protein.

Pub. Date : 2008 Dec

PMID : 18957879






1 Functional Relationships(s)
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1 On the basis of these and other findings, we propose that upregulation of inositol requiring enzyme 1beta, a combined reduction of cellular free cholesterol or triglyceride or both and MTP activity, specific inhibition of phospholipid or triglyceride transfer activities, and targeting of apolipoprotein B-MTP protein-protein interactions might be pursued to avoid some of the side effects associated with the inhibition of triglyceride transfer activity of MTP. Inositol apolipoprotein B Homo sapiens