Pub. Date : 2009 Feb 15
PMID : 18955135
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flavonoids, reported as potent Pgp inhibitors, are able to bind to the cytosolic ATP-binding site and a vicinal hydrophobic pocket. | Flavonoids | phosphoglycolate phosphatase | Homo sapiens |
| 2 | In order to explore the interaction forces governing the affinity of flavonoids towards Pgp, the 3D quantitative structure-activity relationship (QSAR) approach was used to analyze a set of flavonoid derivatives. | Flavonoids | phosphoglycolate phosphatase | Homo sapiens |
| 3 | In order to explore the interaction forces governing the affinity of flavonoids towards Pgp, the 3D quantitative structure-activity relationship (QSAR) approach was used to analyze a set of flavonoid derivatives. | Flavonoids | phosphoglycolate phosphatase | Homo sapiens |
| 4 | The 3D linear solvation energy VolSurf model developed here identifies shape parameters and hydrophobicity as the major physicochemical parameters responsible for the affinity of flavonoid derivatives towards Pgp and hydrogen-bonding capacities as minor modulators of this activity. | Flavonoids | phosphoglycolate phosphatase | Homo sapiens |