Title : Theoretical investigations on the stereoselectivity of the proline catalyzed Mannich reaction in DMSO.

Pub. Date : 2008 Dec 5

PMID : 18954108






1 Functional Relationships(s)
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1 The transformation of syn- to anti-enamine through C-N bond rotation, however, was predicted to require only 4.2 kcal/mol, while the (S)- and (R)-intermediates could be obtained from subsequent reactions between enamine and imine with energy barriers of 8.5 and 12.4 kcal/mol, respectively. Imines synemin Homo sapiens