Pub. Date : 2008 Nov 4
PMID : 18952844
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In this study, we report that Thr-55 phosphorylation induces the association of p53 with the nuclear export factor CRM1, leading to p53 nuclear export. | Threonine | exportin 1 | Homo sapiens |
2 | Interestingly, inhibition of Thr-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association, restores p53 nuclear localization, and sensitizes tumor cells with cytoplasm localized wild-type p53 to DNA damage. | Threonine | exportin 1 | Homo sapiens |