Title : Neuronal nitric oxide synthase-derived hydrogen peroxide is a major endothelium-dependent relaxing factor.

Pub. Date : 2008 Dec

PMID : 18952716






3 Functional Relationships(s)
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1 In mice aorta rings, ACh-induced relaxation was inhibited by L-NAME and Nomega-nitro-L-arginine (L-NNA), two nonselective inhibitors of NOS, and attenuated by selective inhibition of nNOS with L-ArgNO2-L-Dbu-NH2 2TFA (L-ArgNO2-L-Dbu) and 1-(2-trifluoromethylphehyl)imidazole (TRIM). Acetylcholine nitric oxide synthase 1, neuronal Mus musculus
2 Antisense knockdown of nNOS decreased both ACh-dependent relaxation and ACh-induced H2O2 production. Acetylcholine nitric oxide synthase 1, neuronal Mus musculus
3 Antisense knockdown of nNOS decreased both ACh-dependent relaxation and ACh-induced H2O2 production. Acetylcholine nitric oxide synthase 1, neuronal Mus musculus