Title : Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis.

Pub. Date : 2009 Feb

PMID : 18951928






1 Functional Relationships(s)
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1 We show that Zn/PDTC induces p53 proteasomal degradation and that the proteasome inhibitor MG132 further increases fibroblast growth inhibition by Zn/PDTC, suggesting that p53 degradation plays an important role in fibroblast resistance to Zn/PDTC. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens