Title : Mutant huntingtin and mitochondrial dysfunction.

Pub. Date : 2008 Dec

PMID : 18951640






1 Functional Relationships(s)
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1 Here, we highlight how mutant huntingtin (mtHtt) might cause mitochondrial dysfunction by either perturbing transcription of nuclear-encoded mitochondrial proteins or by direct interaction with the organelle and modulation of respiration, mitochondrial membrane potential and Ca(2+) buffering. mthtt huntingtin Homo sapiens