Title : New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.

Pub. Date : 2008 Nov 15

PMID : 18951029






1 Functional Relationships(s)
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1 Transient transactivation studies indicate that modification of the hydrophobic ring impacts dramatically on RXR-binding and transactivation, with most retinoids being inactive on RXRbeta, while preserving their RAR pan-agonist profile. Retinoids retinoid X receptor alpha Homo sapiens