Pub. Date : 2009 Feb 8
PMID : 18929442
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western Blot showed that SN-38 down-regulated protein expression of p-Akt and increased protein expression of p53 and p21, but it had no effects on protein expression of Bax, Bcl-2 and Akt. | Irinotecan | tumor protein p53 | Homo sapiens |
| 2 | Transfection of the full-length Akt cDNA into HeLa and SiHa cells resulted in the reduction of apoptosis induced by SN-38, and Akt kinase activity regulated the p53 pathway, indicating that inhibition of the Akt pathway played an important role in exhibition of SN-38-mediated cytotoxic effect. | Irinotecan | tumor protein p53 | Homo sapiens |
| 3 | Our data suggested that SN-38 could induce apoptosis through a p53 pathway and that activation of p53 in response to S-38 is governed by Akt. | Irinotecan | tumor protein p53 | Homo sapiens |
| 4 | Our data suggested that SN-38 could induce apoptosis through a p53 pathway and that activation of p53 in response to S-38 is governed by Akt. | Irinotecan | tumor protein p53 | Homo sapiens |