Title : A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors.

Pub. Date : 2008 Oct 15

PMID : 18927314






2 Functional Relationships(s)
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Protein Name
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1 We conducted a phase I study of irinotecan and the Hsp90 inhibitor 17AAG, which can also down-regulate Chk1, in patients with solid tumors. tanespimycin checkpoint kinase 1 Homo sapiens
2 Evidence for Hsp90 inhibition by 17AAG, resulting in phospho-Chk1 loss, abrogation of the G(2)-M cell cycle checkpoint, and cell death could be shown in tumor biopsy samples obtained at the MTD. tanespimycin checkpoint kinase 1 Homo sapiens