Title : Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells.

Pub. Date : 2009 Feb 1

PMID : 18922131






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SPT (serine palmitoyl transferase) is a key enzyme regulating ceramide synthesis from palmitate and represents a potential molecular target in curbing lipid-induced insulin resistance. Ceramides alanine--glyoxylate and serine--pyruvate aminotransferase Rattus norvegicus
2 Silencing SPT expression (approximately 90%) by shRNA or chronic cell incubation with myriocin (for 7 days) markedly suppressed SPT activity and palmitate-driven ceramide synthesis; however, challenging these muscle cells with palmitate still inhibited the hormonal activation of PKB. Ceramides alanine--glyoxylate and serine--pyruvate aminotransferase Rattus norvegicus