Title : Fluorescence detection of a lipid-induced tetrameric intermediate in amyloid fibril formation by apolipoprotein C-II.

Pub. Date : 2008 Dec 12

PMID : 18852267






3 Functional Relationships(s)
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1 We have examined the effect of the short-chain phospholipids, dihexanoylphosphatidylcholine (DHPC) and dihexanoylphosphatidylserine (DHPS), on amyloid fibril formation by human apolipoprotein C-II (apoC-II). 1,2-hexanoylphosphatidylcholine apolipoprotein C2 Homo sapiens
2 Micellar DHPC and DHPS strongly inhibited apoC-II fibril formation, whereas submicellar levels of these lipids accelerated apoC-II fibril formation to a similar degree. 1,2-hexanoylphosphatidylcholine apolipoprotein C2 Homo sapiens
3 Emission data for fluorescently labeled apoC-II indicated that DHPC and DHPS stimulate the early formation and accumulation of oligomeric species. 1,2-hexanoylphosphatidylcholine apolipoprotein C2 Homo sapiens