Title : Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation.

Pub. Date : 2009

PMID : 18849610






1 Functional Relationships(s)
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1 Treatment with IMD-0354 inhibited the production of Th2 cytokines such as interleukin (IL)-5 and IL-13 and eotaxin in the airways and/or lungs of OVA-sensitized mice, but it did not affect the restoration of Th1 cytokines such as IL-12 and interferon-gamma under the same experimental conditions. N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide interferon gamma Mus musculus