Title : Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs.

Pub. Date : 2009 Feb

PMID : 18845642






2 Functional Relationships(s)
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1 Ten micromolar of fenamate concentrations inhibited T(4) microvessel uptake with a similar hierarchical inhibition profile [fenamic acid (43%), diclofenac (78%), and meclofenamic acid (85%)], as observed for Oatp1c1 transfected cells. Fenamates solute carrier organic anion transporter family member 1C1 Homo sapiens
2 Together, these data suggest that Oatp1c1 transports fenamates into, and perhaps across, brain barrier cells. Fenamates solute carrier organic anion transporter family member 1C1 Homo sapiens