Title : Apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein are essential factors for nitric oxide-dependent accumulation of p53 in THP-1 human myeloid macrophages.

Pub. Date : 2008 Dec

PMID : 18841476






2 Functional Relationships(s)
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1 In addition, GSNO was found to induce accumulation of p53 in normal but not HIF-1alpha knockdown THP-1 cells, where expression of this protein was silenced by specific siRNA. S-Nitrosoglutathione tumor protein p53 Homo sapiens
2 It has also been found that GSNO-mediated accumulation of p53 depends on activation of ASK1 since no GSNO-induced p53 stabilisation was observed in THP-1 cells transfected with dominant-negative form of this kinase. S-Nitrosoglutathione tumor protein p53 Homo sapiens