Title : Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest.

Pub. Date : 2008 Dec

PMID : 18838534






1 Functional Relationships(s)
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1 We have established a genetically defined differentiation model in human leukemia K562 cells by conditional expression of the cyclin-dependent kinase (Cdk) inhibitor p27 (inducible by Zn(2+)) and Myc (activatable by 4-hydroxy-tamoxifen). 4'-hydroxytamoxifen zinc ribbon domain containing 2 Homo sapiens