Title : An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.

Pub. Date : 2009 Feb

PMID : 18823071






1 Functional Relationships(s)
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1 A novel assay for the determination of l-asparaginase activity in human plasma is described that is based on the HPLC quantitation of l-aspartic acid produced during enzyme incubation. Aspartic Acid asparaginase and isoaspartyl peptidase 1 Homo sapiens