Pub. Date : 2008 Dec 5
PMID : 18822298
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In order to gain more information concerning the tradeoffs associated with active site substitutions, a genetic selection was used to find second site mutations that partially restore ampicillin resistance levels conferred by an R244A active site TEM-1 beta-lactamase mutant. | Ampicillin | CD248 molecule | Homo sapiens |
| 2 | An L201P substitution distant from the active site that enhanced ampicillin resistance levels and increased protein expression levels of the R244A TEM-1 mutant was identified. | Ampicillin | CD248 molecule | Homo sapiens |