Title : Differential activation of ERK and Rac mediates the proliferative and anti-proliferative effects of hyaluronan and CD44.

Pub. Date : 2008 Nov 14

PMID : 18806267






1 Functional Relationships(s)
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Protein Name
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1 HMW-HA binding to CD44 selectively inhibits the GTP loading of Rac and Rac-dependent signaling to the cyclin D1 gene, whereas LMW-HA binding to CD44 selectively stimulates ERK activation and ERK-dependent cyclin D1 gene expression. Guanosine Triphosphate cyclin D1 Homo sapiens