Pub. Date : 2008 Sep 16
PMID : 18799424
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. | tyrosine O-sulfate | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 2 | Here, we report the nuclear magnetic resonance structure of a constitutively dimeric SDF-1 in complex with a CXCR4 fragment that contains three sulfotyrosine residues important for a high-affinity ligand-receptor interaction. | tyrosine O-sulfate | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 3 | CXCR4 bridged the SDF-1 dimer interface so that sulfotyrosines sTyr7 and sTyr12 of CXCR4 occupied positively charged clefts on opposing chemokine subunits. | tyrosine O-sulfate | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 4 | CXCR4 bridged the SDF-1 dimer interface so that sulfotyrosines sTyr7 and sTyr12 of CXCR4 occupied positively charged clefts on opposing chemokine subunits. | tyrosine O-sulfate | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 5 | Our work elucidates the structural basis for sulfotyrosine recognition in the chemokine-receptor interaction and suggests a strategy for CXCR4-targeted drug development. | tyrosine O-sulfate | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 6 | Our work elucidates the structural basis for sulfotyrosine recognition in the chemokine-receptor interaction and suggests a strategy for CXCR4-targeted drug development. | tyrosine O-sulfate | C-X-C motif chemokine receptor 4 | Homo sapiens |