Pub. Date : 2008 Sep
PMID : 18790784
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model. | Cisplatin | transformation related protein 73 | Mus musculus |
| 2 | Cisplatin has been shown to modulate p73 protein level in certain cancer cells. | Cisplatin | transformation related protein 73 | Mus musculus |
| 3 | Our data showed that p73 level was not affected by cisplatin but increased by 1,25D3 in SCC cells. | Cisplatin | transformation related protein 73 | Mus musculus |
| 4 | Knocking down p73 by small interfering RNA protected SCC cells against 1,25D3 and cisplatin-mediated clonogenic cell kill and apoptosis. | Cisplatin | transformation related protein 73 | Mus musculus |
| 5 | Increasing p73 protein level by knocking down UFD2a, which mediates p73 degradation, promoted 1,25D3 and cisplatin-mediated clonogenic cell kill. | Cisplatin | transformation related protein 73 | Mus musculus |
| 6 | These results suggest that 1,25D3 potentiates cisplatin antitumor activity in vitro and in vivo in a SCC model system possibly through p73 induction and apoptosis. | Cisplatin | transformation related protein 73 | Mus musculus |