Pub. Date : 2008 Nov 6
PMID : 18790715
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leptin inhibits rosiglitazone-induced adipogenesis in murine primary adipocytes. | Rosiglitazone | leptin | Mus musculus |
| 2 | In this study, the effects of leptin on rosiglitazone-induced adipocyte differentiation were investigated in the primary preadipocytes prepared from subcutaneous fat tissues of C57BL/6-Lep(ob/ob) mouse. | Rosiglitazone | leptin | Mus musculus |
| 3 | We found that acute and prolonged treatment of leptin on preadipocytes inhibited the rosiglitazone-induced transcription factor expression and adipocyte differentiation, respectively, accompanied with decreased expression of PPARgamma and aP2. | Rosiglitazone | leptin | Mus musculus |
| 4 | Taken together, these data suggest that leptin has a direct inhibitory effect on the rosiglitazone-induced adipocyte differentiation and PPARgamma expression, in which ERK1/2 MAP kinase and JAK/STAT1 signaling pathways are involved. | Rosiglitazone | leptin | Mus musculus |