Pub. Date : 2008 Nov 14
PMID : 18789310
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells. | icariin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Icariin activated the angiogenic signal modulators, ERK, phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric oxide synthase (eNOS), and increased NO production, without affecting VEGF expression, indicating that icariin may directly stimulate angiogenesis. | icariin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results suggest that icariin stimulated angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways and may be a useful drug for angiogenic therapy. | icariin | AKT serine/threonine kinase 1 | Homo sapiens |