Title : [Dendritic cell vaccine modified by murine mAFP gene enhances immunoprotective effect on liver carcinogenesis and tumor development in mice].

Pub. Date : 2008 Apr

PMID : 18788625






2 Functional Relationships(s)
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1 OBJECTIVE: To construct a dendritic cell vaccine transduced by murine alpha-fetoprotein (mAFP) gene, and evaluate its immunoprotective effect on C57BL/6J mice during the induction of hepatocellular carcinoma by diethylnitrosamines, carbon tetrachloride and ethanol. Diethylnitrosamine alpha fetoprotein Mus musculus
2 CONCLUSION: mAFP transgenic DC tumor vaccine inoculation may induce strong immunoprotection against liver carcinogenesis and tumor development and reduce PLC incidence induced by DEN/CCl4/ethanol. Diethylnitrosamine alpha fetoprotein Mus musculus