Pub. Date : 2008 Sep
PMID : 18788099
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased superoxide contributes to enhancement of vascular contraction in Ins2(Akita) diabetic mice, an autosomal dominant mutant model. | Superoxides | insulin II | Mus musculus |
| 2 | Compared with age-matched normal C57BL/6 mice, in Ins2(Akita) diabetic mice arterial superoxide, lipid peroxidation production (1.2 +/- 0.1 vs 17.4 +/- 1.9 mmol/mg tissue, respectively; P < 0.01) and plasma lipid peroxidation production (0.08 +/- 0.02 vs 0.40 +/- 0.03 mmol/L, respectively; P < 0.01) were increased. | Superoxides | insulin II | Mus musculus |
| 3 | These results suggest that increased arterial superoxide generated from diverse sources may potentiate the contractions of carotid arteries in Ins2(Akita) diabetic mice. | Superoxides | insulin II | Mus musculus |