Title : Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae.

Pub. Date : 2008 Oct

PMID : 18780747






1 Functional Relationships(s)
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1 This growth condition alters the epigenetics of rDNA silencing, such that repression of a URA3 reporter gene located at the rDNA induces growth on media that either lacks uracil or contains 5-fluoroorotic acid (5-FOA), an unusual dual phenotype that is reminiscent of telomeric silencing (TPE) of URA3. Uracil orotidine-5'-phosphate decarboxylase Saccharomyces cerevisiae S288C