Title : Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system.

Pub. Date : 2008 Dec

PMID : 18776140






3 Functional Relationships(s)
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1 RESEARCH DESIGN AND METHODS: We measured the hypothalamic phosphorylation of two downstream targets of mTORC1, S6 kinase 1 (S6K1) and S6 ribosomal protein (S6), after administration of the FAS inhibitors C75 and cerulenin in rats. Cerulenin ribosomal protein S6 kinase B1 Rattus norvegicus
2 RESULTS: C75 and cerulenin increased phosphorylation of S6K1 and S6, and their anorexic action was reduced in rapamycin-treated rats and in S6K1(-/-) mice. Cerulenin ribosomal protein S6 kinase B1 Rattus norvegicus
3 RESULTS: C75 and cerulenin increased phosphorylation of S6K1 and S6, and their anorexic action was reduced in rapamycin-treated rats and in S6K1(-/-) mice. Cerulenin ribosomal protein S6 kinase B1 Rattus norvegicus