Title : The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines.

Pub. Date : 2008 Dec 18

PMID : 18774637






1 Functional Relationships(s)
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1 Lapatinib inhibited the phosphorylation of HER2, EGFR and downstream signaling proteins, resulting in G1 arrest in both cell lines with down-regulation of cMyc and induction of p27kip1. Lapatinib MYC proto-oncogene, bHLH transcription factor Homo sapiens