Title : Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin.

Pub. Date : 2008 Oct

PMID : 18772227






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In higher eukaryotic cells, DSBs in chromatin promptly initiate the phosphorylation of the histone H2A variant, H2AX, at Serine 139 to generate gamma-H2AX. dsbs H2A.X variant histone Homo sapiens
2 In higher eukaryotic cells, DSBs in chromatin promptly initiate the phosphorylation of the histone H2A variant, H2AX, at Serine 139 to generate gamma-H2AX. dsbs H2A.X variant histone Homo sapiens
3 Regions in chromatin with gamma-H2AX are conveniently detected by immunofluorescence microscopy and serve as beacons of DSBs. dsbs H2A.X variant histone Homo sapiens