Title : Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells.

Pub. Date : 2008 Oct 31

PMID : 18772138






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
4 The IL-8/AP-1 mutant promoter lacking the sequence immediately upstream the AP-1 site is PGE(2)-unresponsive. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
5 Finally, chromatin immunoprecipitation data confirmed in vivo that PGE(2) induces CHOP binding to the IL-8 promoter. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens