Title : Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

Pub. Date : 2008 Sep 9

PMID : 18768809






1 Functional Relationships(s)
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1 An 8-week treatment with RAD001 (everolimus) suppressed the mTORC1 activity in these polyps and inhibited proliferation of the adenoma cells as well as tumor angiogenesis, which significantly reduced not only the number of polyps but also their size. Everolimus CREB regulated transcription coactivator 1 Mus musculus