Pub. Date : 2008 Dec
PMID : 18765683
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our recent microarray studies revealed induction of FMO2 and FMO3 mRNAs by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver of mice with wild-type aryl hydrocarbon receptor (AHR) but not in Ahr-null mice. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 2 | Our recent microarray studies revealed induction of FMO2 and FMO3 mRNAs by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver of mice with wild-type aryl hydrocarbon receptor (AHR) but not in Ahr-null mice. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 3 | In adult female mice basal FMO3 mRNA is high and was not induced at 4 h but was elevated 8-fold at 24 h. FMO5 mRNA was significantly down-regulated by TCDD in both male and female adult mice. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 4 | Juvenile mice show no sex difference in response to TCDD; FMO3 was induced 4 to 6-fold by TCDD in both sexes. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 5 | Chromatin immunoprecipitation demonstrated recruitment of AHR and aryl hydrocarbon nuclear translocator proteins to Fmo3 regulatory regions, suggesting that induction by TCDD is a primary AHR-mediated event. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |
| 6 | Although FMO2 and FMO3 mRNAs were highly induced by TCDD in adult males, overall FMO catalytic activity increased only modestly. | Polychlorinated Dibenzodioxins | flavin containing monooxygenase 3 | Mus musculus |