Pub. Date : 2008 Dec 18
PMID : 18762368
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | S100P sensitizes ovarian cancer cells to carboplatin and paclitaxel in vitro. | Carboplatin | S100 calcium binding protein P | Homo sapiens |
| 2 | Alternatively, with down-regulation of S100P by siRNA, the IC50 to carboplatin and paclitaxel increased in each case (p<0.05), which was significantly higher compared to untransfected cells. | Carboplatin | S100 calcium binding protein P | Homo sapiens |
| 3 | CONCLUSION: Changes in expression levels of S100P in SKOV3 and OVCAR3 cells results in variable susceptibility to carboplatin and paclitaxel. | Carboplatin | S100 calcium binding protein P | Homo sapiens |
| 4 | These data suggest that S100P contributes to chemosensitivity to carboplatin and paclitaxel in ovarian cancer cells. | Carboplatin | S100 calcium binding protein P | Homo sapiens |