Title : Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.

Pub. Date : 2008 Dec

PMID : 18758753






1 Functional Relationships(s)
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1 Phosphorylation of ERK(1/2) and EGFRs was abolished by AG 1478, an inhibitor of EGFR tyrosine kinases, and GM 6001, an inhibitor of Zn-dependent metalloproteinases, suggesting growth factor "shedding" and transactivation of EGFRs. RTKI cpd mitogen-activated protein kinase 3 Mus musculus